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Less Drastic Ovarian Cancer Surgeries Produce Similar Survival Rates To Traditional Treatments

Premenopausal women with stage one ovarian cancer who have the cancerous ovary removed have the same fiveyear survival rates as women who have both ovaries removed, according to a study published Monday in the journal Cancer, the Los Angeles Times reports. The study also found that fiveyear survival rates were similar for women who had their uterus removed compared with those who did not.

Ovarian cancer treatment traditionally involves removing both ovaries and the uterus, which pushes younger women into menopause. The new study shows that some women may be able to opt for less aggressive surgeries to preserve their fertility, the Times reports. The study was conducted by researchers at Columbia Universitys College of Physicians and Surgeons. Jason Wright the lead author of the study and an assistant professor of womens health at the college said, “Even if people have completed childbearing, there are some hormonal benefits for maintaining the ovaries. So this is something to consider in women 40 to 50.” For example, some studies indicate that women who have their ovaries removed before age 55 have a higher risk for cardiovascular disease, dementia and earlier death, Wright said. However, “[f]or postmenopausal women, the risks may outweigh the benefits,” according to Wright.

Ovarian cancer is the fifthleading cause of cancer deaths in women, occurring most often in postmenopausal women, though as many as 17% of ovarian cancer cases occur in women ages 40 or younger. The disease often is detected in its advanced stages, according to the Times. Because the rate of the cancer among younger women is believed to be increasing, more attention is being paid to preserving fertility. Current options include freezing eggs or embryos prior to the removal of the ovaries (Roan, Los Angeles Times, 8/10).

Reprinted with kind permission from nationalpartnership.org. You can view the entire Daily Womens Health Policy Report, search the archives, or sign up for email delivery here. The Daily Womens Health Policy Report is a free service of the National Partnership for Women & Families, published by The Advisory Board Company.

© 2009 The Advisory Board Company. All rights reserved.

Agosto 14th, 2009 by admin

Platypus Link To Ovarian Cancer

Researchers from the Royal Adelaide Hospital and University of Adelaide believe our oldest mammalian relative may help us to better understand ovarian cancer.

University of Adelaide geneticist, Dr Frank Grutzner says DNA mapping of the platypus has uncovered an interesting relationship between their sex chromosomes and DNA sequences found in human ovarian cancer.

“Weve identified DNA on the sex chromosomes of the platypus that is similar to the DNA that is affected in ovarian cancer and other diseases of reproduction like male infertility,” Dr Grutzner says.

“Cancers often show a large number of DNA changes and it is difficult to decide which ones are important for the development of the disease. The comparison with distantly related species like platypus helps us in identifying important DNA sequences that have been conserved by evolution over millions of years.

“We are excited by the fact that the analysis of the platypus genome gives us new directions in investigating the molecular basis of ovarian cancer.”

Working in partnership with Dr Grutzner is Assoc Prof Martin Oehler, Gynaecological Oncologist specialised in ovarian cancer treatment, from the Royal Adelaide Hospital who says its about finding new ways to tackle the disease.

“We hope this sort of research might one day lead to the development of an early detection test and more effective therapies against ovarian cancer,” Dr Oehler says.

“Ovarian cancer is the most lethal gynaecological cancer and ranks as the 6th most common cause of cancer death in Australian women.”

Both Dr Oehler and Dr Grutzner say the applications of this research are not limited to ovarian cancer, as they try to gain a better understanding of a number of diseases.

Junio 27th, 2009 by admin